The most common change in ocular archaeoplasmosis is granulomatous changes in the unilateral fundus. Diagnosis of granulomatous changes in unilateral fundus: 1. Systemic manifestations Since the larvae not only invade intraocular tissues, but also any other organs and tissues at the same time, they cause fever, malaise, weight loss, cough, wheezing, liver enlargement, itching of trunk and lower limbs, rash and nodules, etc. Individual patients may show manifestations of central nervous system involvement, such as encephalitis, cerebral eosinophil granuloma, epilepsy, etc., but there are also many patients without any systemic symptoms and signs. 2, eye manifestations Eye symptoms may include dark shadows in front of the eyes, vision loss, etc. The degree of vision loss can be very different in different patients. Some patients often have difficulty expressing the exact clinical symptoms due to their young age. The most common change in this disease is a granulomatous change in the unilateral fundus, which is caused by a stage II larva that invades the choroid and forms a capsule. Granulomas can occur in the posterior pole or in the periphery. The posterior pole lesions are 3/4 to 3 optic disc diameters in size and appear as gray or white elevations, often accompanied by mild to severe vitreous inflammatory reactions and decreased visual acuity. Some patients may develop white pupils or strabismus. Peripheral sarcoidosis is a common change that often presents as a white raised lesion in the peripheral fundus that is easily accompanied by a retinal fold. These folds may extend from the periphery to the optic disc, and the peripheral lesions sometimes resemble the snowbank-like changes of intermediate uveitis. Archaeoplasmosis can also cause chronic endophthalmitis, manifested by mild anterior uveitis, posterior iris adhesions, ciliary membrane formation, vitreous inflammation, retinal detachment, and occasionally anterior chamber pus, optic discitis, macular edema, and in some patients, peripheral retinitis, which may be caused by larvae stagnating in the peripheral retinal vessels, and in a few patients, live larvae can be seen in the retinal vessels. Ascaris can also cause neuroretinitis, retinal branch artery obstruction, sclerositis, keratitis, etc. In addition, there are reports of Toxoplasma gondii invading the lens and causing lens masses. Patients usually have a history of dog or cat ownership, and some patients have omnivorous fetishes. Systemic manifestations are suggestive for diagnosis, typical ocular clinical manifestations are valuable for diagnosis, and laboratory tests are important for diagnosis. However, the diagnosis of archaeal ascariasis is generally difficult, because the serological examination of archaeal ascariasis has cross-reactivity with other ascariasis, and the fecal examination is all negative, and some patients have no history of contact with cats or dogs, and the diagnosis can be made only according to the following points: 1. Clinical manifestations There is mainly eosinophilic erythrocytosis, especially limited focal granulomatous inflammation of the fundus, and the vitreous humor is generally cloudy significantly. 2.Serum ELISA method High specificity for toxoplasmosis No significant cross-reactivity with other helminth infections, and higher sensitivity using vitreous examination. The disadvantage is that generally small laboratories are not easy to carry out such tests. 3.Atrial fluid and vitreous aspiration Check for eosinophilic red blood cells. 4.Ultrasound examination Can detect granulomatous lesions, more beneficial to those who cannot be seen in the fundus.