NSAIDs drugs, that is, non-steroidal anti-inflammatory drugs, are drugs commonly used clinically by inhibiting central prostaglandin synthesis to play antipyretic, analgesic, anti-inflammatory and anti-rheumatic effects, mainly selective cyclooxygenase inhibitors, such as meloxicam, celecoxib, nimesulide, etc., and non-selective cyclooxygenase inhibitors, such as aspirin, acetaminophen, indomethacin, ibuprofen, etc.: I. Clinical Applications: 1, antipyretic and analgesic: non-steroidal anti-inflammatory drugs are widely used clinically for fever caused by infection and other reasons, as well as for the treatment of headache, limb pain, nerve pain, toothache, dysmenorrhea and other kinds of pain; 2, anti-inflammatory and anti-rheumatic: non-steroidal anti-inflammatory drugs have anti-inflammatory effects, and are also commonly used in various kinds of inflammation, and can produce certain anti-rheumatic effects for rheumatoid arthritis caused by abnormal immune system; 3 , other: some non-steroidal anti-inflammatory drugs, such as pyrazolones, etc., also have a role in reducing the absorption of uric acid salts by the renal tubules, playing a role in the treatment of gout and so on. It can also induce apoptosis of tumor cells by inhibiting the production of prostaglandins, which can inhibit the growth and metastasis of tumors when used in synergy with other antitumor drugs. Adverse reactions: 1. digestive system: NSAIDs have certain stimulation to the mucous membrane of gastrointestinal tract, which may cause abdominal pain and diarrhea, nausea and vomiting and other gastrointestinal symptoms, so patients with gastrointestinal diseases should use these drugs with caution; 2. kidney damage: these drugs are mainly metabolized by the kidneys, so the kidney burden will increase, and may also reduce the glomerular filtration rate and increase the damage to the kidneys. 3, the central system: such as some patients using aspirin may appear tinnitus vertigo, vision loss and other central system inhibitory effects; 4, the circulatory system: because the non-steroidal anti-inflammatory drugs have inhibitory effects on prostaglandins, may lead to an increase in blood pressure, so hypertensive patients use such drugs with caution; 5, allergic reactions: some patients using non-steroidal anti-inflammatory drugs after Allergic reactions such as skin itching, reddening, rash or asthma, angioedema, etc. may occur, so patients with allergy to such drugs should use with caution; 6. Other: Pregnant women taking such drugs may lead to delivery bleeding, fetal malformation, etc., so pregnant women should use with caution.