Nimesulide extended-release tablets work as anti-inflammatory and analgesic. The drug belongs to the group of non-steroidal anti-inflammatory drugs with anti-inflammatory, analgesic and antipyretic effects, and its mechanism of action is to inhibit the synthesis of prostaglandins. Clinically, it is used to treat pain in chronic arthritis, pain after surgery and acute trauma, symptoms of primary dysmenorrhea. So the drug has an anti-inflammatory and analgesic effect. There are adverse reactions such as heartburn and stomach pain after using the drug; a small number of patients have occasional adverse reactions such as dizziness, drowsiness and skin rash after using the drug. It is forbidden for those who are allergic to any components of this product; those with active peptic ulcer or bleeding; those with severe coagulation disorders, patients with severe heart failure, severe liver and renal function impairment. The smallest effective dose and the shortest course of treatment should be used to minimize the occurrence of adverse drug reactions; liver, kidney and heart functions should be checked regularly during the treatment period; concurrent use of known liver-damaging drugs and excessive alcohol consumption should be avoided during the treatment period; the use of analgesic drugs and the combined application of other non-steroidal anti-inflammatory drugs should be avoided during the treatment period. If medication is needed, it should be used under the guidance of a physician, and should not be used on its own to avoid adverse reactions.