When the patient is allergic to spiramycin, it is usually possible to use other antibiotics, but it needs to be treated according to the actual situation under the guidance of the doctor. Spiramycin belongs to macrolide antibiotics, which is mainly used for the treatment of respiratory tract infections, skin and soft tissue infections, urinary system infections and other diseases caused by sensitive bacteria. If the patient is allergic to spiramycin or other macrolide antibiotics, it is recommended to stop the drug in time and replace other antibiotic drugs under the guidance of the doctor for treatment, such as aminoglycosides, penicillins for treatment, skin test test can be carried out before use, to avoid self-administration of medication, resulting in adverse consequences. Patients in spiromycin, once the allergic phenomenon, it is recommended to go to the hospital in time for examination, and in the doctor’s guidance according to the actual situation to replace the appropriate drugs for treatment. During the use of drug treatment, should pay attention to light diet, avoid eating too spicy, stimulating food.