Sudden shortness of breath and numbness of limbs are considered to be related to hyperventilation syndrome, bronchial asthma, acute respiratory distress syndrome and cardiogenic shock. 1. Hyperventilation syndrome: mainly due to mental and psychological factors leading to the loss of stability of respiratory regulation, the patient may be due to cerebral vasoconstriction, blood oxygen deficiency and sudden shortness of breath, numbness of the limbs and other symptoms. 2. Bronchial asthma: the disease is related to heredity, contact with allergic substances and other factors, the patient’s typical symptoms are wheezing, shortness of breath, chest tightness, coughing, etc., and some patients can also be due to the attack of the disease leads to insufficient blood oxygen in the body, resulting in sudden shortness of breath, tingling of limbs and other phenomena. 3. Acute respiratory distress syndrome: acute respiratory distress syndrome can be caused by a variety of factors such as severe infections and aspiration. Usually, patients are mainly in respiratory distress and refractory hypoxemia, which can be manifested as sudden shortness of breath and numbness of limbs. 4. Cardiogenic shock: mainly due to myocardial necrosis or inflammation, resulting in decreased cardiac contractility and decreased cardiac output, common symptoms include agitation, blurred consciousness, cold extremities, increased respiration, etc., which may also manifest as sudden shortness of breath and numbness of the limbs. Tracheal foreign body, emphysema, acute pulmonary embolism, hypovolemic shock, head trauma, etc. can cause sudden shortness of breath, numbness of the limbs, it is recommended to consult a doctor in time.