Age-related osteoarthritis (OA) or proliferative arthritis, degenerative arthritis, is a common and prevalent disease in the middle-aged and elderly. The incidence increases significantly with age, and he threatens the normal life and activities of about 1/3 of adults worldwide. As humans enter an aging society, the incidence of osteoarthritis is increasing year by year, therefore, correct understanding, active prevention, exact diagnosis and reasonable treatment are very important. The pathogenesis of osteoarthritis is not well understood. The occurrence of osteoarthritis is an active repair process after the destruction of articular cartilage due to multiple causes, and this process is very complex, involving factors such as genetics, endocrine factors, enzyme metabolism, and weight nutrition. The main factors are: (1) Dysregulation of cartilage and matrix synthesis and catabolism. (2) Damage to the subchondral bone plate. (3) Inflammatory response.