Temozolomide is an antineoplastic drug, mainly used in the treatment of adult glioma and malignant melanoma. Its side effects include the following: First, digestive system, decreased appetite, constipation, nausea, vomiting, and generally mild to moderate gastrointestinal disorders can usually be recovered within 1-2 weeks. Second, immune deficiency leading to oral candidiasis infection. Third, hematological system, abnormal blood picture, anemia, neutropenia, thrombocytopenia. Fourth, neurological and psychiatric effects, anxiety, depression, emotional instability, insomnia, visual impairment, hearing impairment, abnormal taste, etc. Fifth, respiratory system, cough, breathing difficulties. Sixth, the skin system, dry skin, allergic reactions, hair loss, rash, etc. Seventh, other, such as muscle weakness, urinary incontinence, etc. According to relevant studies its side effects occur ≥ 10%, but mainly mild gastrointestinal complications, which are generally tolerated by patients.