13-valent pneumonia is 13-valent pneumococcal polysaccharide conjugate vaccine, and 23-valent is 23-valent pneumococcal vaccine. If there is any immunocompromise or old age after receiving 13-valent vaccine, 23-valent vaccine can be considered. However, if you have already received the 23-valent vaccine, you may not receive the 13-valent vaccine. In general, the 13-valent vaccine is mostly used for infants and young children, while the 23-valent vaccine is mostly used for people older than 2 years old, especially for immunocompromised and elderly people. In addition, the 23-valent vaccine basically covers the preventive scope of the 13-valent vaccine, so if you have already received the 23-valent vaccine and your immune function is normal, you can not receive the 13-valent vaccine. It should be noted that if the patient suffers from acute and severe febrile illness, such as acute bronchitis, the vaccine should not be administered to avoid aggravating the patient’s symptoms. Patients with a history of severe allergy to the vaccine are prohibited from receiving the vaccine to prevent allergic symptoms such as shock and respiratory distress. Whether 13-valent pneumococcal polysaccharide conjugate vaccine and 23-valent pneumococcal vaccine are required to be vaccinated, it is recommended that patients consult their doctors before vaccination.