The worst outcome of a gastric sinus biopsy is usually that cancer has occurred. Gastric sinus biopsy usually involves removing the diseased tissues from the gastric sinus area and then analyzing them with pathological examination. The results of pathological examination usually include normal, non-atrophic gastritis, atrophic gastritis, polyp, precancerous lesion, malignant lesion, etc., of which the worst result is usually the occurrence of malignant lesion, which suggests that there is gastric cancer. If gastric cancer is present it needs to be surgically removed and, if necessary, treated with a combination of chemotherapy, radiotherapy, and targeted drugs. If there is any abnormality in the results of the biopsy of gastric sinus, it is recommended to go to the hospital and ask the doctor to make a judgment, and it is not advisable to make a blind judgment on one’s own.