The quadruple vaccine is a vaccine consisting of pertussis, diphtheria, tetanus and Haemophilus influenzae type B. Babies may have systemic or local adverse reactions after receiving the quadruple vaccine. Adverse reactions to the quadruple vaccination include: 1. systemic reactions, fever, drowsiness, and depression. 2. local reactions at the injection site, redness, swelling, hardness, swelling and pain at the injection site. 3. digestive system reactions, with nausea, vomiting, bloating, diarrhea, loss of appetite and eating disorders, 4. skin and subcutaneous tissue reactions, transient urticaria and pruritus. Adverse reactions to DTP vaccine are mild and normal. The main thing is to treat the symptoms, strengthen the care, monitor the body temperature, eat a light diet, give the child more warm water, and pay attention to keeping warm. If the local redness and swelling can be treated by applying cold compresses with a clean towel and hot compresses for hard nodules, and if the fever persists, the child should go to the hospital in time.