Thickening of the mucosa of the maxillary sinus is mainly related to maxillary sinusitis, which is mainly treated by medication and surgery, and the therapeutic effect varies from person to person. Maxillary sinusitis is an inflammatory lesion of the mucosa of the maxillary sinus, with typical symptoms of nasal congestion, runny nose and pus and sputum. Under the long-term stimulation of chronic inflammation can lead to thickening of the mucosa. Common therapeutic agents include penicillin, loratadine, and fluticasone. Among them, mucolytic pro-discharge agents can thin the mucus, improve mucosal cilia activity, and promote the discharge of secretions. Commonly, there are drugs such as Olonma drops. Surgical treatment modalities include radical maxillary sinus surgery and functional sinus endoscopic surgery. After active targeted treatment, most patients’ symptoms can be relieved or disappear. If you find the maxillary sinus mucous membrane thickening, you should consult a doctor in time, under the guidance of the doctor’s treatment, not unauthorized use of medication, in order to avoid delaying the condition. Pay attention to oral hygiene care, quit smoking and drinking, and eat less spicy food.