High leukocytes in the cerebrospinal fluid indicate the presence of inflammation of the cerebrospinal membrane or brain parenchyma, which can be seen in meningitis or encephalitis, and it is recommended that the patient be given a culture of the cerebrospinal fluid, along with an adequate amount of antibiotics. If left untreated, the patient’s infection can lead to increased intracranial pressure, which in severe cases can lead to cerebral herniation, and the patient’s life can be in danger. For cerebrospinal fluid leukocyte high, clinically can be seen in purulent meningitis and part of the tuberculous meningitis patients, also should be given to the patient for cerebrospinal fluid biochemical examination. For cerebrospinal fluid leukocytosis, patients should be given high-level, adequate antibiotic treatment, and also be given physical cooling and other symptomatic treatment to avoid high fever causing convulsions. For high cerebrospinal fluid leukocytes, the treatment of antibiotics at the same time should continue to carry out lumbar puncture to retain cerebrospinal fluid, monitoring the changes of the white blood cell count.