Under normal circumstances, the anal pain relief effect lasts for 4-6 hours with the use of anti-inflammatory pain suppositories, but it also varies according to individual differences and sensitivity, so you need to judge the duration of the pain relief effect according to the specific disease situation, and pay attention to the maintenance of the medication after the anus to avoid the outflow to reduce the effect. The pain around the anus needs to be treated promptly, and pain relief alone does not necessarily play a therapeutic role. The pain in the anus is commonly caused by thrombosed external hemorrhoids and anal fissures, mostly due to prolonged constipation, stool cutting through the mucous membrane or prolonged sitting.