High levels of copper in the body are hepatoblastoid nuclear degeneration, also known as Wilson’s disease. Hepatomegaly, an autosomal recessive disorder, causes copper to accumulate in the body due to an abnormality in the ATP7B gene. It is clinically characterized by three major degenerations: cirrhosis, corneal K-F ring, and extrapyramidal system, with a prevalence of approximately 1:30,000. It is asymptomatic from birth until the onset of the disease. As the amount of copper accumulates in the body increases, children with the disease gradually show symptoms of organ damage, with the most common onset occurring at the age of 5-12 years, and a small number of children are diagnosed with liver function abnormalities found during their physical examination at daycare. Treatment is based on preventing or reducing the accumulation of copper in the tissues, and patients should be treated for life, with early treatment leading to the disappearance of symptoms. The cause of the disease cannot be accurately determined by a single test result, but needs to be combined with the characteristics of the medical history and other test results in order to make an accurate judgment, and it is recommended to clarify the cause of the disease under the guidance of a doctor.