Lower back pain in advanced stage of breast cancer may be due to bone metastasis of breast cancer, which can be treated by systemic radiotherapy, chemotherapy, endocrine therapy, as well as surgical treatment of lumbar spine in order to reduce pain and other clinical symptoms. When breast cancer patients have back pain, it is very likely that lumbar spine metastasis has occurred. Breast cancer is prone to bone metastasis, and it is necessary to evaluate the patient according to the nature of the pain and the degree of the pain, and carry out relevant examinations, including bone scan, thoracic and lumbar spine X-ray and lumbar spine CT or NMR, to further clarify whether the patient’s pain is caused by lumbar spine metastasis. Lumbar metastasis causing back pain can be treated with trastuzumab, patuximab and other drugs for targeted therapy; for specific drugs, please combine the drugs with your own situation and use the drugs under the guidance of a professional doctor; endocrine drugs for premenopausal use, such as triamcinolone acetonide and tamoxifen; and endocrine drugs for postmenopausal use, including aromatase inhibitors, such as exemestane, letrozole, anastrozole and so on. Surgical treatments include palliative lumbar spine cementing and other treatments; thus, reducing the pain and discomfort of the patient and improving the patient’s quality of life. In addition, lumbar pain may also be non-metastatic factors, so you should first go to the hospital to improve the examination to clarify the cause of the treatment as prescribed by the doctor, the drug should be applied under the guidance of the doctor.