There is a possibility of blood in stool during taking hormone medication for nephrotic syndrome. Patients with nephrotic syndrome may have peptic ulcer, gastrointestinal bleeding and other adverse reactions after using glucocorticoids, so there is a possibility of blood in the stool. So clinical attention should be paid to prevention. Nephrotic syndrome is characterized by massive proteinuria, hypoproteinemia, edema, and hyperlipidemia as the basic features. The treatment of nephrotic syndrome includes symptomatic diuresis to reduce swelling and decrease urinary protein. Glucocorticoids are also required to suppress the inflammatory response, diuresis, and elimination of urinary protein. Glucocorticosteroids include hydrocortisone, prednisone and many other hormones. However, there are a series of adverse reactions that may occur during the use of hormones, such as Cushing’s syndrome, withdrawal reactions, and the induction and exacerbation of peptic ulcers. Because glucocorticoids have the potential to cause an increase in gastric acid and pepsin, there is a risk of bleeding and perforation of the gastrointestinal tract leading to blood in the stool. Patients with nephrotic syndrome are advised to go to regular hospitals in time and standardize treatment under the guidance of doctors.