Taking hormones knee pain may be caused by hormone-induced weight gain increased knee load caused by hormones, may also be caused by hormone-induced osteoporosis. 1. Weight gain: hormone itself is a double-edged sword, in the treatment of disease at the same time may also cause weight gain side effects, obesity will lead to an increase in the load on the knee joints, excessive wear and tear of articular cartilage, increased pressure on the soft tissues around the joints and so on, resulting in accelerated wear and tear of the joints, joints in advance of the aging of the compensatory changes, the emergence of the symptoms of knee pain. 2. Osteoporosis: hormone drugs will affect the body’s calcium absorption, if the patient himself is older or supplemental calcium is not timely, may cause the body to develop osteoporosis, osteoporosis of the knee joint will cause a decrease in the stability of the joint, the body in order to fight against the destabilization of the joints, there will be intra-articular hyperplasia of the joints, resulting in symptoms of pain in the knee joints. There may be other reasons for taking hormones for knee pain, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.