The skull is a very important organ in the human body, serving as a hard barrier to protect the brain and head and face, as well as an important guarantee of a smooth operating environment within the skull. Therefore, if a cranial defect occurs, it should be treated promptly. Cranial defects should be repaired as soon as possible at the appropriate time. Usually, after the defect occurs and the recovery from emergency treatment is about three months, cranial repair can be performed. Cranial repair is now a relatively routine surgery in neurosurgery, and the basic problem is not much technically, but mainly lies in the good or bad repair materials. At present, the titanium mesh material used in most hospitals has some less desirable problems, such as the rejection of titanium mesh exposure, various complications, such as the patient’s sensitivity to heat and cold after surgery, such as affecting the postoperative CT and MRI examinations, etc. Currently, the advanced polyetheretherketone PEEK material is used clinically, and this material has become the new favorite in the cranial repair world because of its excellent performance which is almost equivalent to human cranial bone and can achieve very ideal cranial bone repair results.