In general, the normal reference value of ghrelin is 0-40U/L. 52U/L suggests that ghrelin is mildly high, which may be caused by liver diseases such as hepatitis, bad habits such as alcoholism, heart diseases, drugs such as chlorpromazine and toxins such as organophosphorus. 1. Liver diseases: acute and chronic hepatitis, toxic hepatitis, fatty liver, cirrhosis, etc., liver cell damage, necrosis, resulting in a large amount of ghrelin release into the blood, causing serum ghrelin elevation. 2. Bad habits: alcoholism, high salt and high fat diet, long-term late night and other bad habits can cause liver damage, resulting in abnormal liver function, the phenomenon of elevated ghrelin. 3. Heart disease: cardiomyocytes are also rich in ghrelin, when myocarditis, myocardial infarction, etc. can cause myocardial cell damage or even necrosis, releasing ghrelin, resulting in increased serum ghrelin levels. 4. Drugs and poisons: such as chlorpromazine, isoniazid, salicylic acid preparations, carbon tetrachloride, organophosphorus, etc., can lead to increased serum alanine aminotransferase activity. There are many other causes of increased ghrelin, such as malnutrition, skeletal muscle disease and so on. It is recommended to consult a doctor for diagnosis and treatment.