Itchy toe crevices may be caused by physiological factors such as poor skin cleaning, and to a lesser extent, it may be caused by diseases such as athlete’s foot and herpes sweating. 1. Physiological factors: if the foot skin is not clean, or poor hygiene habits, may trigger the toe seam attached dirt, itchy situation. 2. Tinea pedis: clinical manifestations of keratinized scaly skin, increased peeling, itching and other symptoms. The cause of its formation is mostly related to the infection of pathogenic bacteria such as Trichophyton rubrum and Trichophyton mustelii, and the hot and humid environment and impaired immune function may also induce the disease. 3. Sweat herpes: mainly manifested as blisters with intense itching on the hands or feet and other symptoms. The cause of its formation may be related to dermatophyte infection, allergy, and mental, ultraviolet radiation and other factors. There are many reasons for itchy toe crevices, and after excluding physiological factors, patients are advised to seek medical examination to clarify the causes.