The main causes of toothache are as follows: first, caused by diseases of the mucosa of the toothbed, the most common being ulcers of the gingival mucosa, which can lead to the appearance of one or several oval white ulcerated surfaces at the toothbed, which cause ulceration of the mucosal tissue and cause severe pain. Second, due to periodontal disease, patients with periodontitis will suffer from chronic infection resulting in swollen and painful gums. If there is inflammation of the interdental papilla, it will also cause pain in the tooth bed. Third, caused by dental diseases, commonly in patients with pulpitis and periapical periodontitis, the pain in patients with acute pulpitis can be very intense and radioactive, so the patient will also experience pain in the tooth bed along with the pain. In patients with chronic periapical periodontitis, cysts, granulomas and abscesses in the alveolar bone can occur due to inflammation in the alveolar bone, and the tooth can also cause swelling and pain in the tooth bed after eating food. Marginal osteomyelitis due to pericoronitis of the wisdom tooth can also cause pain in the tooth bed.