Rabies vaccine booster shots generally produce a large amount of antibodies within one month of the shot, with the concentration of antibodies reaching 20 U/mL. Usually, antibodies above 0.5 U/mL in the body can protect against the virus. If you have not received a booster shot within one year after receiving five full doses of rabies vaccine, you will also be protected from the virus. If the rabies vaccination has been given for a long time, it is possible that the antibody in the body is lower than 0.5 U/mL and a booster shot is needed immediately. After the booster shot, it is best to inject anti-rabies immunoglobulin again as a precaution. Rabies is a malignant infectious disease, mainly infecting the nervous system, and once infected, there is no medicine available and the mortality rate is 100%. Therefore, even after being bitten by a rabid dog, it is important to have an early booster shot to increase the concentration of antibodies, even if the rabies vaccine has been administered. Patients should note that redness, swelling and pain at the vaccination site may occur after rabies vaccination, and some people may even develop hard nodules and peripheral edema of the injected limb, which can generally resolve on their own and do not require treatment. Try not to take a shower on the day of vaccination to avoid infection at the vaccination site.