It is possible to cure HPV58 squamous epithelial low-grade lesions. Persistent HPV58 (human papillomavirus) infection is an important factor in the development of cervical intraepithelial lesions, as well as cervical cancer, in women. Low-grade cervical squamous epithelial lesions caused by HPV58 infection are at relatively low risk. As the squamous epithelium matures and differentiates, the infection is more easily cleared by the body, and about 60% of low-grade lesions resolve spontaneously. Only follow-up with HPV and cervical cytology is sufficient. If low-grade lesions persist for ≥2 years, local excision or ablation of the lesion may be considered to eliminate the lesion; if colposcopy is unsatisfactory, cervical vertebrectomy may also be considered. It is recommended to seek timely medical standardization, and strictly follow the medical prescription treatment.