Boys taking estrogen for 11 years may lead to the appearance of male feminization, it is not recommended that men take estrogen on their own. Boys taking estrogen for too long may lead to a decrease in androgens in the body and a significant increase in estrogen levels, which can lead to a decline in male secondary sexual characteristics and a significant manifestation of female secondary sexual characteristics, resulting in a decrease in pubic hair, tender skin, mammary gland hyperplasia, a shrill voice, a low libido, and testicular hypoplasia, among other symptoms. Taking estrogen for too long in men may lead to damage due to the above symptoms of endocrine disruption in patients. In the clinical male patients need to supplement estrogen, need to consult the endocrinology department of the regular hospital, do not take on their own.