Syphilis infection has a certain incubation period, because everyone’s constitution is different, the exact time for symptoms to appear varies from person to person, and the majority of patients will have symptoms in about 2-4 weeks. Most patients will experience symptoms in about 2-4 weeks. A few patients may experience symptoms in a few months or even a few years. After the human body is infected with the syphilis spirochete, it usually goes through a period of incubation, and then hard nodules and ulcers appear locally. The length of this incubation period varies from person to person, and can be as short as 10 days to as long as 90 days, with an average of 21 days, or about 2-4 weeks, by which time the spirochetes of syphilis can cause localized contact and skin damage at the site of invasion. Of course, there are some patients who may be infected with the spirochetes of syphilis for a long time without any clinical manifestations, and it is only through blood tests for syphilis that the patient is found to be infected, which is called latent syphilis or hidden syphilis. It is more difficult to determine the time when symptoms appear in these people, some can be a few months, some even more than a few years. If a patient has high-risk behavior and is worried about contracting syphilis, it is recommended that he or she go to the hospital in a timely manner for a definitive examination, so as not to delay his or her condition.