Central air conditioning may transmit coronaviruses. The likelihood of transmission of novel coronaviruses from central air conditioning depends on whether the air conditioning ventilation system is contaminated. Novel coronaviruses are transmitted by respiratory droplets and close contact. It is also spread by aerosols in relatively closed environments. Virus-carrying droplet nuclei entering directly into the ventilation system of an air-conditioner and then mixing and dispersing the air by the central air-conditioner can lead to infection of other people. Droplets with viruses attached to the surface of objects and enter the central air-conditioner, leading to contamination of the air-conditioner. If not properly sterilized, then the new coronavirus can also be transmitted. It is important to avoid high traffic environments and to protect yourself when you go out. Central air-conditioners in crowded public places should be disinfected regularly and in a timely manner. If symptoms such as cough and fever occur, nucleic acid tests should be done in a timely manner to actively cooperate with medical treatment.