The appearance of a vertical line on the soles of the feet is very deep is generally due to nutritional deficiency, tinea pedis, cracked skin and other reasons, you can follow the doctor’s instructions to use general treatment, medication, such as itraconazole tablets and so on. 1. Nutritional deficiency: it is due to the lack of vitamins and trace elements in the body as a result of partiality, picky eating or weight loss, etc. Some patients will have a deep vertical line and peeling skin on the soles of their feet. Patients can go to the hospital, improve the examination, clarify the lack of species and then timely supplementation. 2. Tinea pedis: it is caused by the invasion of skin fungus into the skin of the foot, especially keratinized tinea pedis, which may have very deep fissures. Patients should take itraconazole tablets or terbinafine tablets under the guidance of the doctor, while using ketoconazole ointment externally. Miconazole ointment and other antifungal drugs. 3. Cracked skin: usually caused by dry feet cracked skin, which led to the soles of the feet appeared a very deep vertical lines. Patients are advised to use anti-cracking skin creams or urea ointment to apply, as well as eating foods rich in vitamin A to relieve symptoms. If the soles of the feet appear a very deep vertical lines, it is recommended to go to the hospital in time to identify the cause of the disease and then targeted treatment. The above medications should be used in accordance with medical advice.