Total prostate-specific antigen is the most sensitive marker for prostate cancer and is commonly used for prostate cancer screening and assessing the effectiveness of prostate cancer treatment. Normally, prostate antigen results are less than 4ng/l. Prostatitis, prostate hyperplasia, catheterization, cystoscopy, ejaculation, all of these can lead to elevated prostate-specific antigen. If prostate-specific antigen is persistently elevated and benign diseases are ruled out, then the possibility of prostate cancer should be considered. Therefore, if elevated prostate-specific antigen is found, it is important to go to the hospital as soon as possible to rule out prostate malignancy. If the total prostate-specific antigen is greater than 10 ng/l and a nodule is found on prostate MRI or anal examination, prostate puncture is needed to rule out prostate cancer. Generally speaking, men’s annual physical examination should include prostate ultrasound and total prostate-specific antigen and other indicators, in order to be able to observe the prostate gland in a timely manner, whether there are lesions, and timely detection of changes in the nature of prostate lesions.