Early stage of hepatoportal bile duct cancer often has no special clinical symptoms. When the development of the disease causes bile duct obstruction, obstructive jaundice appears, and the jaundice is progressively aggravated. The disease progresses rapidly. Accompanied by epigastric fullness and discomfort, loss of appetite and obvious emaciation. Some cholangiocarcinoma patients may have suppurative cholangitis as the first symptom, accompanied by chills, fever, paroxysmal pain or distension in the upper abdomen and jaundice. Cancer located in the middle and lower part of bile duct. In abdominal examination, the liver is consistently enlarged and hard, and the enlarged gallbladder can be detected; liver and bile duct cancers located on one side. If the cancer is located on one side of the liver and bile duct, such as left side of the liver and bile duct, there is no obvious symptom. Even when the tumor develops and blocks the opening of the right hepatic duct or invades into the common hepatic duct, obstructive jaundice occurs; when the cancer is located in the common hepatic duct or the confluence part of the left and right hepatic ducts, painless and progressive jaundice can appear in the early stage. Jaundice progresses rapidly, and the liver is consistently enlarged, but the gallbladder is empty and atrophic. In obstructive jaundice, the stool is grayish white. Urine is strong tea-like; advanced patients with severe hepatic and renal function impairment. Patients with severe jaundice, chest and back distension, nausea, vomiting, abdominal distension, ascites, low urine and malignant symptoms. Diagnosis of hepatocellular carcinoma: progressive jaundice (yellowing of eyes, strong tea-colored urine). When accompanied by symptoms such as enlarged liver, loss of appetite and emaciation, it is necessary to consider whether there is this disease. At this time, at least to the hospital for ultrasound and liver function tests. Further, we need to carry out intensive CT of the liver and nuclear magnetic examination of the liver to clarify the typology of the disease and provide guidance for the next step of treatment.