Osteoarthritis of the knee is commonly referred to as degenerative knee joint degeneration, and there is no cure for it. However, appropriate treatment can be given to reduce symptoms and slow the progression of the disease. If you are obese, you should lose weight to effectively reduce the load on the knee joint. You should do less stairs and squats, and maintain appropriate activities, such as walking and non-weight bearing knee extension and flexion activities. If possible, you can do moderate exercise bike training or swimming exercises to maintain joint mobility and strengthen the muscles around the knee joint without causing damage to the knee joint. Keep the joint warm and wear a knee brace if necessary. If there is no significant swelling or fluid in the joint, hot compresses can be applied to improve symptoms. If you are able to, you can also go to the hospital for some rehabilitation physiotherapy. If the pain is severe, you can take some anti-inflammatory painkillers, such as fentanyl or furosemide, etc. For those with gastrointestinal disorders, you can use mupirocort or celebrex, etc., but these drugs should not be taken for a long time. Some drugs such as glucosamine and chondroitin sulfate can be taken, which are also effective for some patients. If medication is contraindicated or ineffective, intra-articular injections of sodium hyaluronate may be used. For those with significant joint effusion, intra-articular injections can be done with some hormones as appropriate, but the use of hormones should not exceed 4 times in a year, and the interval between each time should not be less than 1 week, and if medium and long-acting preparations are used, the interval should not be less than 3 to 4 weeks. If the symptoms of interlocking are caused by free bodies or meniscus rupture in the joint, minimally invasive arthroscopic surgery can be performed to clean up the free bodies and broken meniscus fragments in the joint. For patients whose main symptom is pain, especially pain with weight bearing, arthroscopic surgery is of little value. If it is already in the late stages of osteoarthritis and conservative treatment has not worked, an artificial knee replacement should be considered.