Breast cancer two-negative and one-positive refers to the status of estrogen, progesterone, and HER-2 receptors on the patient’s cancer cells, which means that the patient can receive certain medications. There are three common receptors on the surface of breast cancer cells, which are estrogen receptor, progesterone receptor and HER-2 receptor, and when the expression of the corresponding receptor is positive, it means that the patient can receive the corresponding treatment. If the patient is positive for estrogen receptor or progesterone receptor and negative for other hormone receptors, it means that the patient is effective for endocrine therapy, and commonly used endocrine drugs include tamoxifen, exemestane, letrozole and so on. If the patient is positive for HER-2 receptor expression, it means that the patient can receive anti-HER-2 targeted therapy, and the commonly used drugs are trastuzumab, patuximab and so on. It is recommended that patients go to regular hospitals in time, comprehensive patient condition by clinicians to formulate a suitable treatment plan for patients, and follow the instructions.