Intractable mycosis fungoides needs to be treated with medication and improved lifestyle habits. 1. Drug treatment: check urine sugar and blood sugar, except diabetes. It is recommended to give active treatment for 10-14 days at the beginning, followed by maintenance treatment for 6 months. Such as ketoconazole, 100mg each time, once a day, maintenance for 6 months; or treatment 1 course of treatment at the end of 6 months, each time before menstruation with a vaginal suppository once, a total of 3 days. Mycotoxin tablets, ketoconazole and other commonly used drugs for the treatment of mycosis fungoides, can be used vaginally and taken orally to enhance the efficacy of the treatment, but after the use of diarrhea, nausea, vomiting and other adverse reactions may occur. 2. Improve living habits: patients’ underwear need to be washed separately, scalded with boiling water and exposed to the sun in order to play the role of sterilization and disinfection, usually to eat a light diet, pay attention to local hygiene, and take more rest to avoid exertion. It should be noted that, in the treatment of medication need to strictly follow the doctor’s requirements of medication, can not be unauthorized use of drugs or change the dosage, the rational application of antibiotics and hormones, active treatment of diabetes, is the main measures to prevent infection.