Epididymitis can be treated with cephalosporin and levofloxacin under the guidance of a doctor, but there is no such thing as “which one is better”, and patients should follow the doctor’s instructions. Epididymitis is a non-specific infection of the male reproductive system, and the common causative organisms are Escherichia coli, Mycobacterium tuberculosis, and Staphylococcus. It is necessary for the doctor to choose appropriate drugs, such as ceftazidime and levofloxacin, in conjunction with the results of the patient’s bacterial culture and drug sensitivity test, in order to play a role in controlling the infection. These two types of drugs, with different components, contraindications, adverse reactions, etc., the medication should follow the individual principle, and it is impossible to directly compare which one is better. If the patient has a history of cephalosporin and penicillin allergy, the use of cephalosporin is not recommended. The use of levofloxacin is prohibited in patients younger than 18 years of age if they are allergic to quinolones, pregnant and lactating women. In addition, some patients using cephalosporins may experience adverse reactions such as rash, itchy skin, drug fever, while levofloxacin may cause abdominal pain, diarrhea, dizziness, drowsiness and other side effects. Once discomfort occurs, you should communicate with your doctor and have your medication adjusted by your doctor if necessary. Patients with epididymitis are advised to take medication as prescribed by the doctor and not to change the medication or terminate it without authorization. At the same time, maintain a healthy lifestyle in daily life and do a good job of scrotal protection, which is conducive to the recovery of the body.