A calf soreness at night, may be overworked, calf cold and other physiological factors, may also be lumbar spine lesions, lower extremity venous vascular dysfunction, etc. caused by. 1. Physiological factors: due to walking too long or too much during the day, resulting in calf muscle fatigue, or calf cold, can cause tension spasms in the calf muscles, the body’s metabolites increase, lactic acid accumulation, calf soreness and bloating phenomenon easily appear in the evening when you go to bed. 2. Lumbar spine lesions: Lumbar spine lesions such as disc herniation, lumbar spine slipping, spinal stenosis, etc., can lead to spinal cord or nerve root compression, which can cause lumbar pain and lower limb pain, numbness and swelling symptoms. 3. Lower extremity venous vascular dysfunction: such as lower extremity varicose veins, lower extremity venous thrombosis, lower extremity venous closure insufficiency and other diseases, often lead to the calf part of the venous blood vessel reflux abnormality, caused by venous stagnation, which leads to calf soreness and swelling. Calf soreness at night may also be caused by other reasons, if the symptoms continue to be unrelieved, need to consult a doctor in a timely manner, with the doctor for examination and targeted treatment.