If the pathology of thyroid puncture is benign and the biopsy is malignant, the biopsy result is usually taken as the basis, i.e., malignant, and surgery, radiotherapy and other anticancer treatments should be actively carried out. The benign or malignant nature of thyroid lesions is based on the results of pathological tests. If there is a discrepancy between the results of cytocentesis and tissue biopsy, the results of tissue biopsy should generally be taken as the accurate basis, because the results of cytocentesis may be biased due to the differences in the cell specimens obtained. When the tissue biopsy determines that the thyroid lesion is malignant, i.e., thyroid cancer, the patient must promptly under the guidance of the physician, carry out the correct anticancer treatment, which mainly includes surgical resection, and if necessary, also needs to be combined with radiotherapy, chemotherapy (e.g., cisplatin, mitomycin, etc.), as well as targeted therapy, etc. The patient is advised to maintain a good attitude and be positive. It is recommended that patients keep a good attitude and actively cooperate with doctors for treatment.