Hand blisters peeling skin may be ringworm, eczema, contact dermatitis and other diseases caused by the symptoms, patients should be under the guidance of the doctor for general treatment, drug treatment. 1. Ringworm: ringworm is a disease caused by dermatophyte infection of the skin of the hands. Patients with tinea cruris need to avoid scratching the affected area to prevent self-infection and secondary infection. Patients can use topical ketoconazole cream, terbinafine cream and other antifungal cream. If the external drug treatment is not effective, patients can take oral itraconazole, terbinafine and other drugs. 2. Eczema: Eczema is an inflammatory reaction of the skin caused by internal and external factors, which may lead to blistering and peeling of the hands. Patients can use zinc oxide ointment, hydrocortisone ointment and other topical medications; itching can be combined with the use of cetirizine, chlorpheniramine and other drugs. 3. Contact dermatitis: Contact with allergens can cause blistering and peeling on the hands. Patients should avoid re-exposure to allergens, can be used topically fluoride acetate cream, compound dexamethasone cream and other topical drugs. It can also be combined with oral medications such as loratadine and chlorpheniramine. All of the above drugs should be used under the guidance of a doctor, the patient should not be used on their own, so as not to delay the condition. Patients with hand blisters and peeling skin should go to the hospital in time, under the guidance of the doctor for regular treatment.