Bladder wall thickening and grossness is a condition where the inner wall of the bladder is not smooth and the bladder is thicker than normal when imaging examinations of the bladder, such as ultrasound or CT, are done, mostly due to chronic bladder infections or the presence of chronic irritants. If chronic bladder infection occurs, it can cause surface mucosal congestion and edema, and long-term chronic infection can lead to thickening of the surface mucosa, which can cause the bladder to be slightly thicker than normal. At the same time, because the bladder lining is not smooth due to long-term chronic infection, the appearance of the bladder wall can be gross, and most patients suffer from urinary frequency, urinary urgency, painful urination or hematuria, which requires routine urine laboratory tests and urine culture tests to further confirm the diagnosis. If chronic irritants such as bladder stones and tumors are present, they can lead to localized thickening of the bladder wall with localized mucosal opacification. Further cystoscopy and, if necessary, biopsy can be obtained for characterization. In the presence of neurogenic bladder, it can also cause thickening of the bladder wall with an unsmooth inner wall, which manifests as a gross feeling on imaging, and patients are often associated with type 2 diabetes, cerebral hemorrhage, and cerebral infarction.