Centripetal obesity is commonly seen in Cushing’s syndrome, including ACTH-dependent Cushing’s syndrome and ACTH-independent Cushing’s syndrome. Symptoms of centripetal obesity include thick fat in the chest, abdomen, neck, and back, and later in the course of the disease, when muscle is depleted and the limbs appear relatively thin. Cushing’s syndrome is a general term for conditions caused by excessive secretion of glucocorticoids (mainly cortisol) by the adrenal glands due to a variety of etiologic factors, the most common of which is pituitary hypersecretion of adrenocorticotropic hormone (ACTH) caused by the clinical type known as Cushing’s disease. Clinical symptoms may include centripetal obesity, full moon face, polycythemic appearance, muscle weakness and neurologic symptoms, acne, hypertension, decreased resistance to infection, sexual dysfunction, and metabolic disorders. The symptoms of centripetal obesity are: thick fat in the chest, abdomen, neck and back, and in the later stages of the disease, the limbs appear relatively thin due to muscle depletion. If you find centripetal obesity, it is recommended that patients go to the hospital in a timely manner, under the guidance of the physician diagnosis and treatment, so as not to delay the condition.