When patients have ear pain that prevents them from sleeping, it is often an acute inflammation of the external ear canal or an acute otitis media condition. For this inflammatory factor, the most important thing to use is antibiotic medication. Patients can take oral amoxicillin capsules, cephalexin tablets, and levofloxacin tablets. One can further take orally proprietary Chinese medicines that have the effect of clearing heat and detoxifying and decongesting the swelling, such as Liu Shen Wan and Yi Qing Capsules. For patients with severe ear pain, it is best to go to a hospital to have the cause of the ear pain analyzed. In some cases where the inflammation is more severe, further infusion of anti-infection treatment may be required, and hormonal drugs such as dexamethasone should be used in combination as appropriate to improve the inflammation and swelling symptoms as soon as possible.