1, eliminate the risk factors of chronic renal failure deterioration; 2, adhere to the treatment of the causes of chronic renal failure. Such as chronic nephritis, diabetic nephropathy, all need long-term adherence to treatment; 3, diet therapy. Apply low protein and low phosphorus diet. Application of low-protein diet plus essential amino acids or a-keto acid treatment for pre-dialysis chronic renal failure patients can slow down the decline of blood creatinine count in these patients; 4, reduce glomerular hyperfiltration. Timely control of hypertension is important in delaying the development of chronic renal failure. The use of angiotensin-converting enzyme inhibitors has a mitigating effect on hyperfiltration in diabetic nephropathy, etc., and can slow down the rate of creatinine elevation; 5. Reduce tubular-interstitial calcium and phosphorus deposition. Such as low phosphorus diet, phosphorus binding agents, etc., and others such as certain vitamin D3; 6, correction of hyperuricemia. Application of unsaturated fatty acids, lipid-regulating drugs, etc., may have the effect of slowing down glomerulosclerosis; 7, reduce the accumulation of uremic toxins. Such as low-protein diet, keep the stool open, intestinal dialysis, etc.; 8, calcium antagonists. May have slowed down the role of glomerulosclerosis, the mechanism may be related to the control of hypertension, reduce glomerular filtration, and reduce calcium and phosphorus deposition in renal tissue; 9, anti-platelet drugs. May have reduced renal microcirculation thrombosis, slowing down the role of glomerulosclerosis, need further observation; 10, other drugs. Blood-activating drugs, antioxidants, etc.