Acute sinusitis in children can be treated with antibiotics such as Amoxicillin Clavulanate Potassium, combined with hormonal medications such as Ephedrine Nasal Drops and Mometasone Furoate Nasal Spray, depending on the pathogenic bacteria. Acute sinusitis in children is mostly an inflammatory disease caused by bacterial infection of the mucous membranes in the sinus cavities of children, which manifests itself in symptoms such as nasal congestion, runny nose and headache. Most of them are triggered by upper respiratory tract infections. The first step in the treatment of sinusitis in children is to use sensitive antibiotics to control the infection, especially penicillin or cephalosporin antibiotics, such as amoxicillin clavulanic acid potassium, cefaclor and so on. Nasal cavity and sinus localization can use glucocorticoid drugs for anti-infection treatment of nasal mucosa, such as mometasone furoate nasal spray. At the same time, physiological seawater spray can be combined to clean the purulent secretions in the nasal cavity. Ephedrine nasal drops can be used briefly when secretions are high to improve nasal ventilation. Children with sinusitis, need to be otolaryngology consultation, to clarify the cause of the disease, and follow the doctor’s instructions for treatment.