Usually, taking probiotics for Helicobacter pylori infection has a supporting role. Probiotics can play a role in improving the intestinal flora, thus exerting the effects of body regulation, collective defense and disease prevention. After taking probiotics, patients can inhibit the inflammatory response in the body to a certain extent and promote the recovery of the gastrointestinal mucosa. Some compound probiotic preparations can inhibit Helicobacter pylori and reduce the adverse reaction of drugs in the process of eradicating Helicobacter pylori treatment. Therefore, taking probiotics for H. pylori infection has a certain auxiliary effect. However, patients with H. pylori infection can not only use probiotics, but also need to carry out quadruple therapy, such as amoxicillin, clarithromycin, omeprazole, colloidal bismuth pectin, and so on. In addition, it is recommended that patients with H. pylori infection go to the hospital in time and follow the doctor’s instructions. Probiotics also need to be used under medical supervision.