A stabbing pain in the middle of the chest may be caused by sternum fracture, chest wall disease, cardiovascular disease, tumor and so on. 1. Sternum fracture: if the chest is fractured due to trauma, impact and other factors, a stabbing pain in the middle of the chest may occur. 2. Chest wall diseases: such as costochondritis, usually in the intercostal nerve innervated area of the pain, the pain can be dull pain, may lead to a burst of stabbing pain in the middle of the chest. 3. Cardiovascular diseases: such as coronary heart disease, myocardial ischemia, etc., usually caused by the decrease of blood perfusion in the heart, which usually leads to the pain in the left precordial area, but sometimes it can also be manifested as a burst of stabbing pain in the middle of the chest. 4. Tumor: If there is a tumor in the chest, or malignant tumor metastasizes to the chest, causing poor blood circulation, it may also lead to a burst of pain in the middle of the chest. This symptom alone is not enough to diagnose the disease, but may be caused by other factors. It is recommended that the patient should consult the doctor in time, ask the doctor to clarify the cause of the disease and give targeted treatment.