Chronic atrophic gastritis with enterorrhea is one of the more serious ones and should be treated promptly. Chronic atrophic gastritis develops from chronic superficial gastritis, and enterocolitis is a manifestation of the aggravation of the condition. If not treated in time, atypical abnormal hyperplasia may appear, and this abnormal hyperplasia belongs to precancerous lesions. Chronic atrophic gastritis is mostly caused by Helicobacter pylori infection, and should be treated in time, routinely recommended bismuth + PPI + two antimicrobial drugs composed of quadruple therapy as a first-line treatment program, such as bismuth potassium citrate + omeprazole + metronidazole + amoxicillin, the specific drugs need to be in the gastroenterologist’s guidance of the medication. Diet, it is recommended to eat light and easily digestible food, less spicy stimulation, fried food, so as not to stimulate the gastric mucosa, aggravate the condition. In conclusion, if you suffer from chronic atrophic gastritis with intestinalization, you must actively cooperate with the doctor’s treatment, and regularly review the gastroscope. If lesions are found, timely surgical treatment.