Spherocytosis can be seen in hereditary spherocytosis, which usually cannot be treated with medication and must be treated with surgery. Spherocytosis is usually caused by an autosomal dominant disorder, or in a small percentage of cases, an autosomal recessive disorder. Since small spherical red cells are mainly caused by the spleen destroying the normal red blood cells, the most reliable treatment option for this disease is splenectomy. After splenectomy, the shape of red blood cells can be repaired, but after splenectomy, there will also be many complications, such as anemia, gallstones, etc. After the surgery, patients should be checked regularly for changes in the number of red blood cells and platelets. Patients should go to the hospital for examination in time, and it is better to carry out surgical treatment in time to alleviate the condition, which cannot be cured by relying on drugs alone. Specific treatment should be carried out under the guidance of physicians.