Multiple lymph nodes 1cm in hepatoportal area should be treated differently according to different causes, the common causes are inflammation, tuberculosis, cancer and so on, which can be treated by medication, surgery and so on. 1. Inflammation: cholecystitis, cholangitis, chronic hepatitis and other inflammatory diseases may cause the display of multiple lymph nodes in the hilar region, which can be treated with cephalosporin and other drugs, such as cefoperazone, cefuroxime, etc. If the condition is serious, surgical treatment is needed, such as laparoscopic cholecystectomy, pancreatic cholangiopancreatography and lithotripsy. Chronic hepatitis needs to be treated according to the cause of hepatitis, such as entecavir and other antiviral treatment. 2. Tuberculosis: Mycobacterium tuberculosis infection of the liver may invade the hilar lymph nodes with lymphatic fluid, resulting in enlarged hilar lymph nodes. Anti-tuberculosis treatment, such as isoniazid and rifampicin, should be actively carried out. 3. Cancer: Cancers such as bile duct cancer, gallbladder cancer, liver cancer and stomach cancer may cause enlarged lymph nodes in the hilar lymph nodes due to primary cancer or metastasis, which should be actively treated with anticancer therapy, such as radiotherapy or surgery. Chemotherapy drugs include cisplatin, albumin paclitaxel, etc. Surgical options include partial hepatectomy and pancreaticoduodenectomy. All of the above drugs should be used under the supervision of a doctor. Multiple lymph nodes in the hepatoportal area may also be caused by other reasons, and should be promptly consulted in the hospital to identify the cause and provide targeted treatment.