Skin pustules are divided into infectious and non-infectious, the first need to clarify the cause of the treatment, mainly for drug treatment. Infectious pustules are caused by bacterial infection, the main drug treatment, light can be localized external mupirocin ointment, ciprofloxacin ointment and other drugs for treatment; serious cases should be given systemic treatment, preferred penicillin, cephalosporin, and so on. Non-infectious pustules may be caused by mosquito venomous stimulation, and some of the causes are unknown, and its treatment is based on the treatment of the primary disease, such as cryptococcal dermatitis pustules caused by the use of chlorpheniramine, chlorotetracycline, etc.; pustular psoriasis caused by pustular psoriasis pustules treated with avitaminosis A, methotrexate and so on. The use of drugs should be under the guidance of medical professionals to avoid adverse reactions.