Mild interstitial lung changes are generally not serious, mainly to attract attention, if it is idiopathic pulmonary fibrosis in both lungs, the early mild interstitial lung changes are easily misdiagnosed as acute interstitial pneumonia, and active anti-infective treatment and hormone therapy are given, after treatment if the interstitial changes disappeared, it means that the mild interstitial changes are not serious. If the clinical manifestations such as cough, wheezing, dyspnea, and severe hypoxia are not corrected after treatment, the mild interstitial changes have progressed to severe idiopathic interstitial fibrosis, which requires long-term home oxygen therapy and noninvasive ventilator treatment. There are also some systemic diseases that cause interstitial lung changes, such as systemic lupus erythematosus, rheumatoid arthritis, dermatomyositis, scleroderma, etc. These diseases will lead to interstitial lung changes in the later stages and develop from mild to severe. Therefore, when clinically encountering mild interstitial lung changes, it is important to understand the specific disease and the prognosis of the disease in order to give targeted treatment to control the disease as early as possible, so as not to allow mild interstitial lung changes to develop into severe interstitial lung fibrosis.