Enhanced thickening of liver parenchymal echogenicity may be caused by fatty liver, acute viral hepatitis B, cirrhosis and other diseases. Patients can choose appropriate treatments, such as medication and general measures, according to different causes. Drugs should be applied under the guidance of doctors. 1. Fatty liver: the thickening of liver parenchyma echogenicity may be caused by fatty liver, patients can enhance the exercise, usually avoid eating high fat content food, such as fat meat, barbecue, etc., and quit smoking and alcohol. 2. Acute viral hepatitis B: If liver parenchymal echogenicity is thickened due to acute viral hepatitis B, patients can take oral antiviral drugs, such as entecavir tablets as prescribed by the doctor. Oral polyene phosphatidylcholine capsules, silymarin capsules and other drugs to protect the liver cell membrane. 3. Cirrhosis: actively targeting the causes of cirrhosis for treatment, such as alcohol cessation, anti-hepatitis virus treatment, treatment of autoimmune liver disease. When cirrhosis reaches the end stage, liver transplantation is recommended. Patients with thickening of liver parenchymal echogenicity can consult a doctor to clarify the cause of the disease and then follow the doctor’s instructions for treatment.