ECL cells are the major endocrine cells within the mucosa of the gastric body and are closely related to intragastric acidity and plasma gastrin concentration. ECL cells, i.e., enterophilic chromaffin-like cells, are found mainly in the fundic glands of the stomach, mostly at the base or body of the glands and rarely in the neck. The cells were in closed type, the top of which did not reach the surface of the gland lumen, often buried between the mural cells and the main cells, and the basal surface was close to the basement membrane.The ECL cells were small in size, irregular in morphology, and strongly silversophilic. The ECL cells are small in size, irregular in morphology, and strongly silversmithic. Electron microscopy reveals vacuolated granules with diameters of about 250 nm or 450 nm. In the digestive system, histamine stimulates the secretion of mural and principal cells, causing spasmodic contraction of smooth muscle, relaxation of blood vessels (smooth muscle) and increased capillary permeability. It is worth proposing that histamine, gastrin and acetylcholine have mutually reinforcing effects in stimulating gastric acid secretion from mural cells, with histamine playing a key role.